Abstract #3851

Orientation Dispersion Index identifies sub-areas in the edema tissue of glioblastoma

Giulia Debiasi^1,2, Alessandro Salvalaggio^3,4, Maria Colpo^2,3, Diego Cecchin⁵, Maurizio Corbetta^3,4,6, and Alessandra Bertoldo^2,3

¹Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy, ²Department of Information Engineering, University of Padova, Padova, Italy, ³Padova Neuroscience Center, University of Padova, Padova, Italy, ⁴Department of Neuroscience, University of Padova, Padova, Italy, ⁵Nuclear Medicine Unit, Department of Medicine, Padova University Hospital, Padova, Italy, ⁶Veneto Institute of Molecular Medicine, Padova, Italy

Synopsis

Keywords: Tumors (Pre-Treatment), Tumor

Motivation: Edema tissue in glioblastoma is not included in surgical resection, even though tumor cells infiltration could be mediated by it.

Goal(s): The aim of the study is to investigate the heterogeneity of edema.

Approach: Clustering analysis within edema is performed on the orientation dispersion index derived from diffusion magnetic resonance imaging. Then, a non-parametric statistical test is carried out to assess the difference between the resulting edema sub-tissues (e.g., clusters).

Results: Two spatially separated clusters are found for all subjects. Statistically significant differences are observed between each couple of resulting clusters.

Impact: Edema is not a healthy tissue and the possibility of identifying sub-tissues within it could aid clinical practice and pre-surgical planning. This study works at single-subject level, allowing the focus on the specific glioblastoma cases.

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