Abstract #3868

Brain asymmetries from midlife to old adulthood and hemispheric brain age

Max Korbmacher^1,2,3, Dennis van der Meer^2,4, Dani Beck^2,5,6, Eli Nina Eikefjord^1,3, Ann-Marie de Lange^2,7,8, Arvid Lundervold^1,3,9,10, Ole A. Andreassen^2,11, Lars T. Westlye^2,6,11, and Ivan I. Maximov^1,2

¹Department of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway, ²NORMENT Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway, ³Mohn Medical Imaging and Visualization Centre (MMIV), Bergen, Norway, ⁴Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands, ⁵Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway, ⁶Department of Psychology, University of Oslo, Oslo, Norway, ⁷LREN, Centre for Research in Neurosciences - Department of Clinical Neurosciences, CHUV and University of Lausanne, Lausanne, Switzerland, ⁸Department of Psychiatry, Oxford University, Oxford, United Kingdom, ⁹Department of Radiology, Haukeland University Hospital, Bergen, Norway, ¹⁰Department of Biomedicine, University of Bergen, Bergen, Norway, ¹¹KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway

Synopsis

Keywords: Aging, Aging, Asymmetry

Motivation: The human brain demonstrates structural and functional asymmetries which have implications for ageing and the development of mental and neurological diseases. Age-relationships
of these asymmetries are largely unknown.

Goal(s): We aimed to map brain asymmetries from midlife to older ages and develop hemispheric
brain age (HBA) models, which consider apparent hemispheric differences.

Approach: We used structural and diffusion magnetic resonance imaging metrics (N=48,040, UK Biobank) to evaluate the age-relationship of brain asymmetry.

Results: Most metrics indicated asymmetry, which appears lower at higher age in white matter and
higher in grey matter. HBA reflects other brain ages and unique information of each hemisphere.

Impact: We present for the first time comprehensive analyses of brain asymmetries throughout midlife and older ages and establish a new conceptualisation of BrainAge. This ”hemispheric” BrainAge can serve as a marker of asymmetry by comparing left to right hemisphere-derived BrainAges.

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