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Abstract #3889

Brain maps of pCO2, pO2 and pH in aging via homeostatic modeling of neuroimaging data across the lifespan

Silvia Mangia1, Mauro DiNuzzo2, Gerald A Dienel3,4, Kevin L Behar5,6, Helene Benveniste7,8, Federico Giove9,10, Suzana Herculano11, Michael Wolf1, Xiufeng Li1, Pavel Filip12, Shalom Michaeli1, and Douglas L Rothman5,7
1Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, United States, 2Netabolics, Rome, Italy, 3Neurology, University of Arkansas, Little Rock, AZ, United States, 4Cell Biology and Physiology, University of New Mexico, Albuquerque, NM, United States, 5Radiology, Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, United States, 6Psychiatry, Yale University, New Haven, CT, United States, 7Biomedical Engineering, Yale University, New Haven, CT, United States, 8Anesthesiology, Yale University, New Haven, CT, United States, 9Centro Ricerche Enrico Fermi, Rome, Italy, 10Fondazione Santa Lucia IRCCS, Rome, Italy, 11Psychology, Vanderbilt University, Nashville, TN, United States, 12Department of Neurology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

Synopsis

Keywords: Aging, Aging, Brain, modelling, metabolism, arterial spin labeling, neurovascular coupling, oxygen extraction fraction

Motivation: How loss of vascular health in aging leads to loss of brain function remains unexplained, since paradoxically brain energy consumption is close to normal.

Goal(s): Our goal is to determine whether the loss of vascular health impacts the tissue accumulation of metabolic nutrients and waste products, which may interfere with brain function.

Approach: We exploited Homeostatic Modeling to obtain brain maps of pCO2, pO2 and pH from two retrospective PET and MRI datasets.

Results: Our results show that reduced vascular health in the elderly leads to regional loss of pCO2, pO2, and pH homeostasis of potential clinical significance.

Impact: Determining whether impaired vascular health results into loss of homeostasis of metabolic waste products is critical to guide interventions that improve or preserve brain health in aging and beyond, including neurological conditions such as dementia, stroke, and traumatic brain injury.

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Abstract

Keywords