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Abstract #3890

Longitudinal changes in cerebral metabolic rate of oxygen (CMRO2) in older adults without and with cognitive impairment

Jiani Wu1, Kumiko Oishi2, Anja Soldan3, Corinne Pettigrew3, Zixuan Lin4, Yuxin Zhu3, Dengrong Jiang4, Xin Li4, Abhay Moghekar3, Peiying Liu4, Kenichi Oishi4, Marilyn Albert3, and Hanzhang Lu1,4,5
1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Center for Imaging Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States, 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Aging, Aging

Motivation: Cerebral metabolic rate of oxygen (CMRO2) reflects the brain’s energy consumption and neural function. Longitudinal CMRO2 changes in the aging brain have not been fully characterized.

Goal(s): Our goal was to study longitudinal CMRO2 changes in cognitively normal older adults and examine differences in CMRO2 between participants without and with cognitive impairment.

Approach: CMRO2 was estimated from MRI measurements. Linear mixed effect (LME) models were employed to evaluate the relationship between CMRO2 and the related independent variables.

Results: CMRO2 decreased with age cross-sectionally and increased with follow-up time longitudinally. CMRO2 was lower in cognitively impaired participants compared to cognitively normal participants.

Impact: The present work revealed a bell-shaped trajectory of CMRO2 in aging. CMRO2 may also be a promising biomarker of neurogenerative diseases.

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Abstract

Keywords