Abstract #3905

Effect of diagnostic and genetic status on the relationship between rs-fMRI complexity and tau & amyloid PET in Alzheimer’s disease.

Kay Jann¹, Steven Cen², Mariella Santos³, Dilmini Wijesinghe¹, Ru Zhang¹, John M Ringman², and Danny JJ Wang¹

¹USC Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ²Department of Neurology, University of Southern California, Los Angeles, CA, United States, ³Department of Public Health, California State University Fullerton, Fullerton, CA, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, fMRI (resting state), Complexity, Amyloid, Tau, APOE4

Motivation: Decreased brain function in Alzheimer’s Disease can be assessed by complexity of resting-state fMRI. Specifically, in precuneus and medial temporal lobe rsfMRI-complexity is reduced in MCI and AD and negatively associated with tau-PET uptake. However, its association with amyloid deposition or effects of genetic characteristics (APOE4) remains unknown.

Goal(s): To investigate the association between rsfMRI-complexity, tau-PET and amyloid-PET as well as influence of APOE4 status.

Approach: Multivariate linear models assessing rsfMRI-complexity, tau-PET, amyloid-PET and APOE4 in select regions of interest.

Results: rsfMRI-complexity shows a strong significant inverse relationship with tau but not amyloid and APOE4 increases this effect.

Impact: We show that rsfMRI-complexity shows a strong association with tau but not amyloid deposition and that genetic risk in form of APOE4 strengthens this effect. Thus rsfMRI-complexity adds a novel tool to investigate impaired brain functionality in AD progression.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.