Abstract #3906

Quantification of Tau in the Piriform Cortex in AD using MR-PET

Hossein Moein Taghavi¹, Mahta Karimpoor¹, Eric van Staalduinen¹, Samantha Leventis¹, Christina B Young², Mackenzie Carlson², Hillary Vossler², Guido Davidzon¹, America Romero², Alexandra Trelle², Jarrett Rosenberg¹, Victor Henderson², Greg Zaharchuk¹, Kathleen L Poston², Marios Georgiadis¹, Elizabeth Mormino^2,3, and Michael Zeineh¹

¹Department of Radiology, Stanford University School of Medicine, Stanford, CA, United States, ²Department of Neurology, Stanford University School of Medicine, Stanford, CA, United States, ³Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, MR-PET

Motivation: Olfactory dysfunction can be an early sign of Alzheimer’s disease (AD), but involvement of primary olfactory piriform cortex in AD pathology is unknown.

Goal(s): We use Tau MR-PET to compare piriform cortex uptake to the adjacent medial temporal lobe across the progression of AD pathology.

Approach: Using PI-2620 Tau MR-PET, we manually segmented and computed piriform tau compared to automatically segmented medial temporal uptake in amyloid negative/positive healthy controls, mild cognitive impairment, and AD subjects.

Results: Piriform tau uptake increases ordinally with disease severity and is significantly different higher in amyloid positive compared to negative controls.

Impact: We show early increases in piriform cortex tau uptake that closely track adjacent medial temporal regions. This not only explains deficits in olfaction early in AD but opens the door to more sensitive testing and comprehensive detection of neurodegeneration.

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