Keywords: Alzheimer's Disease, Neurodegeneration, CSF clearance, Choroid plexus
Motivation: Impaired Alzheimer's disease (AD) pathological protein clearance plays a critical role in the progression of cognitive impairment.
Goal(s): To explore whether microscale abnormalities in clearance pathways exhibit macroscopic imaging patterns.
Approach: Data collection was performed, and quantitative features were calculated for intergroup differences and correlation analysis.
Results: The specific imaging patterns represented by choroid plexus and its associated alterations are associated with increased brain AD pathological protein burden and decreased clearance capacity of the glymphatic system.
Impact: This study provides a novel perspective on the decreased clearance capacity of amyloid-beta and tau proteins in cognitively impaired patients' brains. The discovery of distinct imaging patterns aids in accurate diagnosis, treatment, and deepens our understanding of Alzheimer's disease mechanisms.
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