Keywords: Alzheimer's Disease, Alzheimer's Disease, subjective cognitive decline, mild cognitive impairment, amplitude of low-frequency fluctuation/fractional amplitude of low-frequency fluctuation, cortical thickness
Motivation: Numerous neuroimaging studies have reported that Alzheimer's disease and preclinical AD have been linked to alterations in the amplitude of low-frequency fluctuation /fractional ALFF and cortical thickness of some brain areas.
Goal(s): However, the findings have been inconsistent and the correlation with the transcriptional profile and neurotransmitter systems remain largely unknown.
Approach: We conducted a meta-analysis to identify multimodal differences in ALFF/fALFF and CT in patients with AD and preclinical AD, using the Seed-based d Mapping with Permutation of Subject Images software.
Results: Overlapping meta analysis showed that patients with AD displayed decreased ALFF/fALFF and CT in the left PCC.
Impact: These findings may provide different insights into the pathophysiology of AD spectrum.
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