Abstract #3946

Biomechanical properties and multiparametric MRI to identify microstructural dynamics in a non-alcoholic steatohepatitis mouse model

Yasmine Safraou¹, Kristin Brüggemann¹, Biru Huang¹, Christian Bayerl¹, Karolina Krehl², Anja Kühl³, Tom Meyer¹, Mehrgan Shahryari¹, Pedro Dantas de Moraes¹, Jakob Jordan¹, Noah Jaitner¹, Heiko Tzschätzsch⁴, Ingolf Sack¹, Patrick Asbach¹, Jing Guo¹, and Jürgen Braun⁴

¹Department of Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany, ³iPATH Berlin Core Unit, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁴Institute of Medical Informatics, Charité – Universitätsmedizin Berlin, Berlin, Germany

Synopsis

Keywords: Biology, Models, Methods, Elastography, Preclinical, Steatohepatitis, Murine model, Viscoelasticity, Water diffusion, Fat content

Motivation: The relationship between the microstructural changes and the imaging-based biophysical properties of the liver as NASH progresses are not fully established.

Goal(s): We aim to identify quantitative imaging markers that can provide valuable insights into the microstructural progression of NASH.

Approach: We established non-alcoholic steatohepatitis in mice with a defined amino-acid high-fat diet. We performed MRI, MR elastography and histological scoring with automated fat segmentation at different times during the course of NASH.

Results: Our results shed light on liver viscosity and water diffusivity as potential quantitative markers of steatohepatitis progression in mice.

Impact: This study highlights the role of multiparametric-MRI, MR elastography and histopathology to reveal the dynamics of microstructural changes of non-alcoholic steatohepatitis in a mouse model using a clinical scanner. We identify liver viscosity and water diffusivity as reliable quantitative markers.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.