Keywords: Small Animals, Cardiovascular, T1 mapping
Motivation: Preclinical cardiac T1 mapping in high field encountered a great challenge, such as rapid heart rate, B0 and B1 inhomogeneity, which affects both accuracy and precision in T1.
Goal(s): We aim to develop an accurate, fast and reproducible T1 mapping method at 9.4 T MRI.
Approach: We adapted inversion efficiency (IE) to the segmented Look-locker sequence and validated it in a phantom, as well as in aorta banding rats.
Results: Segmented Look-Locker T1 mapping with IE is a fast and accurate T1 mapping method, which corrects the imperfection of inversion pulse in high field.
Impact: We have developed a rapid, highly precise T1 mapping technique for rat hearts using 9.4 T MRI, enabling longitudinal scans and comparisons between different animals.
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