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Abstract #3950

Shear-induced Sodium Dynamics within Red Blood Cells membrane using advanced 23Na Single and Triple Quantum Filtered Rheo-NMR methods.

Galina E Pavlovskaya1, Mark E McBride2, Raheela Khan2, Nick Selby3, and Thomas Meersmann1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Royal Derby Hospital, University of Nottingham, Derby, United Kingdom, 3Centre for Kidney Research and Innovation, University of Nottingham, Derby, United Kingdom

Synopsis

Keywords: Biology, Models, Methods, Spectroscopy, sodium, rheology, red blood cells

Motivation: Increased blood viscosity has been reported in red blood cell senescence and pathologies of decreased perfusion such as chronic kidney disease.

Goal(s):

  • Rheological NMR is a powerful, although still underutilized, tool to assess the molecular-mechanical links in flowing media. This study's primary objective was to explore the dynamic alterations in Na+ interaction with glycocalyx of red blood cells exposed to the physiological shear forces experienced within the microvasculature in health and disease.

Approach: 23Na multiple quantum filtered (MQF) rheo-NMR in RBCs suspensions at varied haematocrit.

Results: 23Na MQF rheo-NMR are efficient to detect Na+ interaction with glycocalyx of red blood cells under deformation

Impact: Potential sodium “rheo-markers” reflective of blood viscosity in health and disease are proposed.

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Abstract

Keywords