Abstract #3961

A novel ADAMTS-specific MR peptide probe for characterization of atherosclerotic plaques in a murine model

Dilyana Branimirova Mangarova¹, Jan Ole Kaufmann^1,2, Julia Brangsch¹, Avan Kader¹, Jana Moeckel¹, Jennifer Lilly Heyl¹, Christine Verlemann³, Lisa Christine Adams⁴, Antje Ludwig ⁵, Carolin Reimann¹, Wolfram Poller⁵, Peter Niehaus³, Uwe Karst³, Matthias Taupitz¹, Bernd Hamm¹, Michael Weller², and Marcus Makowski⁴

¹Radiology, Charite Universitaetsmedizin - Berlin, Berlin, Germany, ²Division 1.5 Protein Analysis, Federal Institute for Materials Research and Testing (BAM), Berlin, Germany, ³Institute of Inorganic and Analytical Chemistry, Westfaelische Wilhelms-Universität Muenster, Muenster, Germany, ⁴Diagnostic and Interventional Radiology, Technische Universitaet Muenchen, Munich, Germany, ⁵Department of Cardiology and Angiology, Charite Universitaetsmedizin - Berlin, Berlin, Germany

Synopsis

Keywords: Probes & Targets, Atherosclerosis, ADAMTS4

Motivation: A precise diagnosis of atherosclerosis is of clinical importance, since cardiovascular disease remain one of the leading causes of death worldwide.

Goal(s): The goal of this study was to evaluate the feasibility of characterizing a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS4) using molecular magnetic resonance imaging in a preclnical model of atherosclerosis.

Approach: Molecular magnetic resonance imaging using a novel probe targeted against ADAMTS4 was used in a high-fat murine model.

Results: It was possible to image atherosclerotic lesions in a mouse model using an ADAMTS4- specific probe for magnetic resonance imaging.

Impact: Using molecular MRI targeting ADAMTS4 is a promising method for characterization of plaque composition and could possibly impact plaque vulnerability assessment in the diagnosis and treatment of atherosclerosis in patients.

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