Keywords: Biology, Models, Methods, High-Field MRI
Motivation: The zebrafish is an important model organism for the study of vertebrate biology with its genomes showing significant parallels to human genomes.
Goal(s): To show the feasibility of in-vivo imaging at a pre-clinical 11.7T MRI without the need for dedicated hardware components.
Approach: A budget-friendly zebrafish holder was created using a syringe barrel and needle adapters, with a rotating cylinder to maintain water flow. It was positioned on a Bruker Mouse Brain Surface Coil.
Results: The use of standard imaging equipment in combination with a low-cost and easy to built animal holder is sufficient to facility high-resolution imaging of the adult zebrafish.
Impact: This research enables cost-effective, high-resolution MRI for zebrafish, enhancing its potential as a pre-clinical model for vital research in vertebrate biology, ultimately advancing our understanding of human genomics.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords