Keywords: Other Preclinical, Toxicity, In vitro Pharmacometabolomics, NMR spectroscopy, Nanocomposite, Nanotoxicology
Motivation: Conventional toxicity assays generally convey the efficiency of nanomaterial, but they lack a mechanistic molecular approach to toxicity.
Goal(s): We aimed to employ NMR-based Pharmacometabolomics to detect early metabolic alterations associated with nanomaterial developed for healthcare.
Approach: The NMR spectroscopy technique was used on Silver nanoparticles reinforced biocomposite exposed murine fibroblast (L929) cells.
Results: Results demonstrated that cellular metabolic profiles reset towards control upon more exposure.
Impact: Our nanomaterial-based study accentuates the role of pharmacometabolomics, which will complement the findings of conventional assays, eventually leading to efficacious clinical translation.
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