Keywords: Biomarkers, Vessels, Liver, tumor, biomechanics, Elastography
Motivation: Colorectal cancer is a major global cause of cancer-related deaths, often metastasizing to the liver. Standard treatment includes chemotherapy and anti-angiogenic therapy. Quantifying therapy efficacy remains a clinical challenge.
Goal(s): We explore multifrequency MR-Elastography (MRE) for assessing vascular organization, using a murine liver metastasis model correlated with histopathology.
Approach: The study used MRE imaging of murin liver metastasis model and the corresponding histopathology to analyze vascular organization (fractal dimension), by measuring Hurst index (H-index).
Results: The H-index differs significantly between tumor and healthy liver tissue, with normal vasculature displaying a lower H-index compared to the tumoral tissue.
Impact: Our in vivo elastography study demonstrates the organization of the vascular network by matching with histological findings. This innovative approach paves the way for non-invasive evaluation of treatments targeting tumor vessels, such as bevacizumab or FOLFOX.
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