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Abstract #3977

Amide proton transfer-weighted MRI in predicting tumor budding grade of rectal adenocarcinoma: A prospective pilot study

Peiyi Xie1, Qitong Huang1, Litao Zheng1, Jiao Li1, and Xiaochun Meng1
1The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Synopsis

Keywords: Cancer, CEST & MT

Motivation: Tumor budding (TB) is an important additional prognostic factor for patients with colorectal cancer (CRC).

Goal(s): Accurate TB assessment before surgery can help guide clinical decisions and improve patient prognosis.

Approach: This study explored the feasibility of amide proton transfer-weighted (APTw) MR imaging in assessing TB grade in patients with rectal cancer (RC).

Results: We found that RC lesions with high-grade TB had higher APTw 90th percentile values than low-grade TB.

Impact: APTw MRI may be beneficial for implementing more accurate personalized treatment and improving tumor prognosis.

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