Abstract #3991

Aplastic Anemia in the Adults: Capability of Proton Density Fat Fraction Quantification for Hematopoietic Ability Assessment and Diagnosis

Yoshiharu Ohno^1,2, Yuichiro Sano³, Kaori Yamamoto³, Maiko Shinohara³, Masato Ikedo³, Masao Yui³, Hiroyuki Nagata², Takahiro Ueda⁴, Masahiko Nomura⁴, Takeshi Yoshikawa^4,5, Daisuke Takenaka^4,5, and Yoshiyuki Ozawa⁴

¹Diagnostic Radiology, Fujita Health University School of Medicine, Toyoake, Japan, ²Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University School of Medicine, Toyoake, Japan, ³Canon Medical Systems Corporation, Otawara, Japan, ⁴Radiology, Fujita Health University School of Medicine, Toyoake, Japan, ⁵Diagnostic Radiology, Hyogo Cancer Center, Akashi, Japan

Synopsis

Keywords: Screening, Hematologic, Proton density fat fraction

Motivation: PDFF quantification (PD-FFQ) with 6-point Dixon technique has a potential to assess hematopoietic ability assessment and diagnosis of aplastic anemia in adults.

Goal(s): The goal was to determine the capability of PD-FFQ with 6-point Dixon technique for diagnosis of aplastic anemia in adults.

Approach: Gender and age matched aplastic anemia patients and adults without aplastic anemia examined lumber MRI with PD-FFQ, and %CV and SD for vertebral bone marrow fat fraction were assessed and tested for differentiating two groups.

Results: When applied feasible threshold value, specificity of %CV was significantly higher than that of SD (p=0.03).

Impact: Proton density fat fraction quantification (PD-FFQ) with 6-point Dixon technique has a potential for hematopoietic ability assessment and diagnosis of aplastic anemia in adults.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.