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Abstract #3996

Optimizing b-value Selection in MRI Diffusion Parameters for Hepatocellular Carcinoma: A Comparative Study of IVIM, DKI, and CTRW Models

Fan Zhang1, Gen Chen1, Zixiong Wang1, Mnegqi Huang1, Ting Yin2, Wei Chen2, and Xuemei Hu1
1Huazhong University of Science and Technology, Wuhan, China, 2MR Research Collaborations, Siemens Healthineers Ltd., Shanghai, China

Synopsis

Keywords: Liver, Body

Motivation: Streamlining the number of b-values in MRI scans for hepatocellular carcinoma can significantly enhance diagnostic efficiency.

Goal(s): To identify the minimal b-value pairs that correspond with comprehensive diffusion model parameters, potentially simplifying future scanning protocols.

Approach: Employed MRI diffusion parameters across 11 b-values in 35 patients, comparing IVIM, DKI, and CTRW metrics with sADC values derived from varied b-value combinations.

Results: Discovered specific b-value pairs that closely matched the diffusion parameters of comprehensive models, suggesting a possible reduction in required b-values for accurate diagnosis.

Impact: This study could substantially refine MRI protocols, improving tumor characterization and grading while ensuring data quality with fewer b-values.

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