Keywords: Alzheimer's Disease, Alzheimer's Disease
Motivation: Resting-state fMRI studies of Alzheimer’s disease impact on brain’s function commonly use functional connectivity (FC) ignoring sensitive and dynamic readouts such as the co-activation patterns (CAPs) occurring at short timescales.
Goal(s): We aimed to assess changes in CAPs, in addition to network-level FC, in a transgenic rat model of Alzheimer’s disease longitudinally.
Approach: We acquired high temporal resolution resting-state fMRI and performed FC and CAP analysis.
Results: We found increased lateral cortical network FC that correlated with memory impairments at the plaque stage, and hyper and hypoactivation of the default-mode-like-network and hippocampal regions in two CAPs at the pre-plaque and plaque stages respectively.
Impact: Our findings demonstrate that metrics of brain dysfunction of Alzheimer’s disease derived from high temporal resolution resting-state fMRI not only explain behavioural manifestations but also capture alterations preceding plaque formation further validating their translational potential as an early, functional biomarker.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords