Keywords: Alzheimer's Disease, Alzheimer's Disease
Motivation: The sex-specific brain alteration in cognitively normal older adults with amyloid-β pathology was unclear.
Goal(s): This study aimed to investigate the impact of sex and APOE genotype on the functional connectivity of the entorhinal cortex (ERC) in cognitively normal older adults with amyloid-β pathology.
Approach: Using a large sample from the A4 study, the authors performed a comprehensive analysis comparing demographic information, cognitive performance, volumetric MRI data, and ERC functional connectivity.
Results: Results revealed sex-specific differences in ERC connectivity, with males showing higher connectivity in the sensorimotor network and females exhibiting higher connectivity in the default mode, executive control, and reward networks.
Impact: This study sheds light on the influence of sex and APOE genotype on the functional connectivity of the entorhinal cortex in cognitively normal older adults with amyloid-β pathology.
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