Meeting Banner
Abstract #4044

Large-scale dynamic functional connectivity alterations in subjective cognitive decline: a rs-fMRI study on 5T MRI

Futao Chen1,2, Lixian Zou2, Xiang Fan3, Guanxun Cheng3, Ye Li2, Dong Liang2, Xin Liu2, Hairong Zheng2, and Bing Zhang1
1Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, 2Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 3Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, 5TMRI, Dynamic Functional Connectivity, Independent Component Analysis

Motivation: Subjective cognitive decline (SCD) is considered to be the best window period for early diagnosis and intervention of Alzheimer’s disease (AD). However, large-scale dynamic functional connectivity (DFC) alterations in this stage remain unclear.

Goal(s): To assess alterations in large-scale DFC in SCD patients on 5T MRI.

Approach: With a sliding-window approach and k-means clustering based on independent component analysis, rs-fMRI of high spatial-temporal dimension was used to evaluate large-scale DFC properties in SCD and normal control (NC) on 5T MRI.

Results: Four distinct functional states were identified. DFC properties were statistically significantly different between SCD and NC in state 2 and state 3.

Impact: Our study is the first successful attempt in fMRI of high spatio-temporal dimension on 5T MRI datasets. Altered temporal properties in large-scale DFC may serve as sensitive neuroimaging biomarkers for the preclinical detection of individuals with incipient AD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords

functional