Abstract #4045

One year aerobic exercise improved fitness, cognition, reduced arterial stiffness and brain vascular reactivity to CO2 in amnestic MCI

Suhaas Penukonda^1,2, Takashi Tarumi^3,4, Min Sheng^2,5, Tsubasa Tomoto^3,4, Munro C. Cullum^6,7, Rong Zhang^3,8, Hanzhang Lu^2,9, and Binu P. Thomas^2,10

¹Department of Biomedical Engineering, University of Texas at Dallas, Dallas, TX, United States, ²Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United States, ⁴National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan, ⁵The Hospital for Sick Children, Toronto, ON, Canada, ⁶Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁷Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁸Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁹Department of Radiology and Radiological Science, John Hopkins University School of Medicine, Baltimore, MD, United States, ¹⁰Department of Bioengineering, University of Texas at Arlington, Arlington, TX, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, Cerebrovascular Reactivity, Aerobic Exercise, Cardiorespiratory Fitness, Carotid Artery Stiffness

Motivation: The benefits of long-term aerobic exercise (AE) on brain function in amnestic mild cognitive
impairment (aMCI) patients is not fully understood.

Goal(s): This study assesses long-term benefits of AE on cerebrovascular reactivity (CVR) in aMCI in
relation to cognition, cardiorespiratory fitness and carotid arterial stiffness.

Approach: 27 aMCI patients were assigned randomly to either AE or stretching and toning (ST) groups.
CVR MRI, cardiorespiratory fitness, cognition, carotid arterial stiffness using ultrasound were
measured before and one-year after AE or ST intervention.

Results: One-year intervention improved fitness and cognition, decreased arterial stiffness and CVR in
the AE group, not different in the ST group.

Impact: Long-term aerobic exercise (AE) intervention in amnestic MCI patients improved cardiorespiratory fitness and cognition, reduced arterial stiffness and cerebrovascular reactivity(CVR), suggesting that long-term AE improves cognition and vasculature; CVR reduction is suggestive of vascular adaptations to long-term AE.

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