Keywords: Alzheimer's Disease, Perfusion, adiposity, obesity
Motivation: Understanding the role of midlife obesity in Alzheimer disease (AD) risk is key to AD prevention.
Goal(s): We aimed to investigate the association between obesity and abdominal visceral and subcutaneous adipose tissue (VAT, and SAT) and brain perfusion, altered early in AD.
Approach: For this aim, we performed brain and abdominal MRI scans to compare absolute cerebral blood flow (CBF), derived from pCASL sequence, between the obese vs. non-obese, the high- vs. low-VAT and high- vs. low-VAT groups.
Results: A lower whole-brain CBF was observed in the obese vs. non-obese and high-VAT vs. low-VAT, but not between high- and low-SAT groups.
Impact: Lower brain perfusion in individuals with obesity and higher VAT, especially in AD-related areas like middle temporal cortex, highlights midlife visceral obesity’s role in AD development. Future studies should explore the association of AD neuroimaging markers with body mass components.
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