Keywords: Other Neurodegeneration, Degenerative, Multiple system atrophy
Motivation: Functional brain network studies of freezing of gait have been extensive in PD in recent years, but are still lacking in MSA, where the disease deteriorate more rapidly.
Goal(s): Investigate the disrupted topology of functional interactions in MSA-FOG. Extend our knowledge of the neurobiological basis of FOG in MSA.
Approach: We constructed and analysed functional network at global, node and modular levels when compared among MSA patients with and without freezing of gait and matched healthy controls.
Results: The aberrations of visual network, DAN and coupling changes between visual network and cerebellum were found in MSA-FOG compared to MSA-nFOG and HC.
Impact: Different from focusing on pairwise brain regions, our study proved MSA-FOG FC alterations in the visual network and the dorsal attention network as well as coupling pattern changes between visual network the other networks at the large-scale network level.
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