Keywords: Dementia, Alzheimer's Disease, Aging, TAR DNA-binding protein 43, TDP-43, Neurodegeneration, PET, MRI
Motivation: TDP-43, a 43kDa protein in the brain, plays a crucial role in neurodegenerative disorders and is a potential target for clinical trials. Confirmation currently requires an autopsy.
Goal(s): To explore potential antemortem biomarkers for early-stage TDP-43 detection using conventional MRI and 18F-FDG-PET scans.
Approach: Blinded visual evaluations of MRI and 18F-FDG-PET scans were performed utilizing specialized rating scales.
Results: TDP-43(+) cases exhibited more medial temporal atrophy on MRI, though influenced by age. Visual inspection of MRI and 18F-FDG-PET changes could aid early TDP-43 prediction, although further research employing advanced neuroimaging and statistical techniques is essential to identify more robust early-stage TDP-43 neuroimaging biomarkers.
Impact: Predicting TDP-43 status holds substantial diagnostic and clinical significance. TDP-43 could emerge as a promising therapy target in neurodegenerative disorders and a critical consideration in clinical trials. Early-stage TDP-43 prediction offers valuable insights into disease prognosis and progression.
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