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Abstract #4089

Parallel transmit spatial-spectral pulse design with specific absorption rate control for water excitation: validation in humans at 7 Tesla

Xin Shao1, Zhe Zhang2, Xiaodong Ma3, Fan Liu1, Hua Guo1, Kamil Ugurbil4, and Xiaoping Wu4
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Tiantan Neuroimaging Center of Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 3Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, 4Center for Magnetic Resonance Research, Radiology, Medical School, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Parallel Transmit & Multiband, Parallel Transmit & Multiband

Motivation: Last year we demonstrated the utility of our new parallel transmit spatial-spectral pulse design for robust water excitation, but only using Bloch simulations without experimental proof.

Goal(s): Our goal here was to validate our method via phantom and human scans at 7 Tesla.

Approach: We validated our design method by collecting 3D GRE data in a water-fat phantom and in the human brain. All data were obtained on a Siemens Terra using the commercial Nova 8-channel transmit coil.

Results: Our method outperformed existing approaches, producing uniform water excitation across the whole brain with nearly complete fat suppression even in the challenging areas.

Impact: Validated in humans at 7 Tesla, our design method provides an effective solution for volumetric uniform water excitation, eliminating the need for additional fat saturation and holding a promise to many applications including high-resolution functional MRI at ultrahigh field.

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