Keywords: Small Animals, Alzheimer's Disease, resting state fMRI, functional connectivity, tau
Motivation: Identifying neurological changes in Alzheimer’s Disease (AD) is critical for early intervention. Tau accumulation is a key pathological feature in AD and other neurodegenerative diseases.
Goal(s): This project investigates how tau accumulation impacts structural and functional connectivity in the brain and cognitive decline.
Approach: We use behavioral assessments of learning and memory in the rTg4510 mouse model of tauopathy with awake resting-state fMRI and diffusion tensor imaging at three timepoints during the course of tau accumulation.
Results: As tau accumulates, we identify patterns of functional connectivity changes. We plan to use machine learning to link these changes to cognitive decline.
Impact: We study how tau accumulation affects brain functional connectivity and cognitive decline in a mouse model of tauopathy. Magnetic resonance imaging may offer non-invasive tools for assessing Alzheimer's Disease pathology, potentially aiding in early diagnosis.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords