Keywords: Biology, Models, Methods, Translational Studies, Huntington's
Motivation: Suitable mouse models of Huntington's disease are crucial for the evaluation and translation of potential new treatments.
Goal(s): We studied the zQ175 heterozygous model for Huntington's disease in comparison to wildtype controls.
Approach: We compared brain MRI and behavioral readouts over a large part of the lifespan to characterize and quantify phenotypes.
Results: The model only developed a mild brain atrophy phenotype, part of the size difference was shown to be due to reduced growth rather than atrophy.
Impact: This study can help researchers to make better informed decisions on mouse model selection for evaluation of potential treatment efficacy in translational studies of Huntington's disease.
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