Keywords: Preclinical Image Analysis, Segmentation, Parcellation, atlas based volume extraction
Motivation: Manual characterization of brain regions is studied without prior knowledge to identify changes in GM/WM volume in PD.
Goal(s): Characterisation of GM and WM changes in 6-OHDA PD model as compared to sham control
Approach: Parcellated the rat brain into predefined regions using a rat atlas and performed the Wilcoxon rank signed rank test to identify significant changes in GM/WM volume.
Results: Significant loss in GM volume of a few brain regions in PD and Sham observed in 3rd and 7th week. Increase in WM volume for 3rd week is observed.
Impact: We identified GM loss and WM gain in a few brain regions without manual intervention which helps in understanding the structural changes in the whole brain in PD and Sham.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords