Keywords: Biology, Models, Methods, Aging, elastography
Motivation: The biomechanical signature of the aging brain and its correlation with the underlying microstructure, is poorly understood.
Goal(s): To systematically analyze the global and regional biomechanical properties of the brain during aging.
Approach: We investigated the in vivo biomechanical progression of the female mouse brain over an age range of 6 to 18 months using multifrequency MR elastography.
Results: Highly resolved elastographic atlases of the mouse brain at different ages were generated. Global and regional analysis revealed softening and reduced viscosity as dominating patters of biomechanical changes related to the structural variations of the aging brain.
Impact: This study demonstrated the use of MR elastography to track the biomechanical changes in the brains of aging healthy mice. Our study revealed softening and increased viscosity as biomechanical signature of the aging brain.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords