Keywords: Neurotransmission, Metabolism, Glucose, glutamate, GABA, Neurons, neurotransmission
Motivation: Fasting is used in weight loss but its impact on brain activity is not well understood.
Goal(s): To assess the impact of prolonged fasting on the excitatory and inhibitory neurotransmission in the brain.
Approach: Infuse [1,6-13C2]glucose in mice fasted for 4h to 60h, and measure 13C labeling of brain metabolites by 1H-[13C]-NMR spectroscopy.
Results: The glutamatergic neurometabolic activity was reduced in the cerebral cortex of mice fasted for 60 h.
Impact: These findings can be used for modifying the fasting paradigm in different interventions involving fasting.
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