Keywords: Small Animals, Spectroscopy, X-nuclei, dynamic 13C, mice brain, cerebral metabolism
Motivation: Dynamic 13C MRS is a powerful tool for the investigation of brain metabolism in vivo. Due to its low SNR, it is typically constrained to big voxel sizes covering almost the whole brain in mice. Thus, making region specific research questions difficult.
Goal(s): Investigating the feasibility of acquiring 13C spectra from a distinct brain region (bilateral hippocampi) in the mouse brain at 9.4T.
Approach: We applied a combination of polarization transfer, a CryoProbe, frequency correction and ‘SVD denoising’ for the acquisition of 13C spectra.
Results: We achieved sufficient spectral quality to quantify even small metabolite pools like GABA in the bilateral hippocampus.
Impact: 13C MRS of distinct brain regions in the mouse brain paves the way for more specific research questions.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords