Keywords: Biology, Models, Methods, Neuroscience, fMRI Analysis, brain connectivity, preclinical
Motivation: We do not yet know where zona incerta (ZI) neural activity is distributed in central pathways despite extensive knowledge of incertal projections and functions.
Goal(s): We aim to reveal the long-range functional pathways of ZI neural activity to bridge the knowledge gap between known anatomical projections and implicated functions.
Approach: We deployed optogenetic fMRI to directly initiate neural activity at ZI and computational approaches to characterize the downstream central pathways involved.
Results: The propagation of neural activity from ZI are not restricted to monosynaptic projections within known subcortical structures, but along multi-synaptic, long-range central pathways.
Impact: Characterization of ZI functional pathways is of tremendous value to neuroscientists and clinicians for future in-depth investigations of key/previously undefined incertal regions and for designing more effective therapeutic measures such as deep brain stimulation, where ZI is a key target.
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