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Abstract #4138

Using Time-Dependent Diffusion MRI for Microstructural Evaluation in Hepatocellular Carcinoma

Jiansun Li1, Yuchen Wei1, Chenhui Li1, Chen Zhao2, Thorsten Feiweier3, and Jinyuan Liao1
1The department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China, 2MR Research Collaboration, Siemens Healthineers, Guangzhou, Guangdong, China, 3MR Research Collaboration, Siemens Healthineers, Erlangen, Germany

Synopsis

Keywords: Liver, Diffusion/other diffusion imaging techniques

Motivation: The purpose of this study is to assess the microstructural parameters of hepatocellular carcinoma by the time-dependent diffusion MRI technique.

Goal(s): Demonstrate the feasibility of TDD-MRI for evaluating hepatocellular cancer cell size with little difference from pathological verification.

Approach: This prospective study will perform TDD-MRI scans for HCC patients before surgery; the cell size of tumor tissue samples obtained from surgery was measured and set as the gold standard.

Results: Data of 13 patients was collected, while there was no remarkable relationship between the TDD-MRI extracted results and histological measurements.

Impact: Although our results show no statistically significant for now, TDD-MRI has still got certain potential values in the application of liver tumors, while the measurement of pathological samples need to be optimized further.

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