Abstract #4139

Assessing Hepatic Metabolism in Patients with HCC Using 31P-MRS: Insights and Potential Clinical Utility

Jingzhe Li^1,2, Huimin Lin², Fuhua Yan^1,2, Yuchen Yang³, Yinghua Guo⁴, Yiming Wang⁴, and Zhongping Zhang⁴

¹Faculty of Medical Imaging Technology, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;, Shanghai, China, ³Department of General Surgery, Ruijin Hospital，Shanghai Jiao Tong University School Of Medicine, Shanghai, China, ⁴Philips Healthcare, Shanghai, China, Shanghai, China

Synopsis

Keywords: Liver, Liver, Phosphorus Magnetic Resonance Spectroscopy

Motivation: The clinical need for noninvasive tools to assess the metabolism of hepatocellular carcinoma (HCC), which contributes to treatment guidance, therapy response assessment and prognostic prediction. This study aimed to investigate the value of phosphorus (31P)-magnetic resonance spectroscopy (MRS) as a supplementary metabolism-related alternative in clinic.

Goal(s): The goal of this study was to evaluate the metabolism status of HCC, compared with healthy controls.

Approach: Three HCC patients and three healthy volunteers were analyzed with a 3.0-T MRI scanner, using 31P MRS.

Results: The study revealed an elevated phomonoester (PME) / phosphodiester (PDE) ratio in patients with HCC, suggesting potential metabolic changes in HCC.

Impact: This study highlights the promising value of 31P MRS as a noninvasive alternative in patients with HCC. Elevated PME/PDE ratio offers valuable insights into hepatocellular carcinoma, enhancing the diagnostic and treatment strategies of HCC.

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