Abstract #4148

Value of Preoperative Magnetic Resonance Elastography for Wnt/β-catenin Pathway Activation and MVI Expression in Hepatocellular Carcinoma

Huanhuan Chong¹, Huimin Lin¹, Yuchen Yang², Jiahao Zhou¹, Yikun Wang¹, Jing Guo³, Ruokun Li¹, and Fuhua Yan¹

¹Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Department of Radiology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany, Berlin, Germany

Synopsis

Keywords: Liver, Liver, Hepatocellular carcinoma, Magnetic resonance elastography, Wnt/β-catenin signal pathway, Microvascular invasion, Prognosis

Motivation: Non-invasive detection of MVI and Wnt/β-catenin pathway activation remains challenging for hepatocellular carcinoma (HCC).

Goal(s): To investigate Wnt/β-catenin pathway and MVI expression in HCC using preoperative magnetic resonance elastography (MRE).

Approach: Totally, 210 HCC patients undergoing hepatectomy were recruited for preoperative MRE and recurrence-free survival was documented. Tumor c and φ value represented tissue stiffness and viscosity, respectively.

Results: The silence of Wnt/β-catenin pathway and the presence of MVI-positivity were markedly prone to postoperative recrudescence. Besides, an increased tumor c value was identified as independent risk factors for Wnt/β-catenin pathway activation, while a decreased tumor c value was strongly linked to MVI-positivity.

Impact: This study focuses on the contribution of biomechanics to HCC aggressiveness within the context of signal pathways and tumor microenvironment, and on clinical significances of integrating MRE into clinical practice for optimizing treatment decisions and enhancing risk stratification in HCC.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.