Keywords: Hepatobiliary, Liver, Chronic liver disease; Impaired Glucose Tolerance;T1-mapping Magnetic Resonance Imaging; Eextracellular Volume Fraction
Motivation: The mechanism of impaired glucose tolerance (IGT) in chronic liver disease (CLD) may be related to reduced insulin secretion caused by pancreatic fibrosis.
Goal(s): This study aims to evaluating the value of T1-mapping MRI in quantifying pancreatic ECV fraction for predicting IGT in CLD.
Approach: A total of 184 CLD patients were recruited in this study. Univariate and multivariate logistic regression analysis was conducted to identify independent predictors of IGT in CLD.
Results: After adjusting for age, gender, body mass index(BMI), hypertension,estimated glomerular filtration rate(eGFR), cholesterol and triglycerides, pancreatic ECV fraction was identified as an independent predictor for IGT in CLD.
Impact: The results suggest that pancreatic ECV fraction, quantified by T1-mapping MRI, may help elucidate the pathophysiological mechanisms of IGT in CLD.
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