Abstract #4195

The role of glymphatic system dysfunction in multiple system atrophy and its impact on disease-related pathological changes

Boyu Chen¹, Nana Zhang^1,2, Yueluan Jiang³, Guoguang Fan MD，PhD¹, Shenxia Zhang¹, and Yuzi Fan Wang⁴

¹Radiology, The First Hospital of China Medical University, Shenyang, China, ²Department of Radiology, The Second Hospital of Dlian Medical University, Dalian, China, ³MR Research Collaboration, Siemens Healthineers, Beijing, China, ⁴Department of Radiation Oncology, The First Hospital of China Medical University: The First Hospital of China Medical University, Shenyang, China

Synopsis

Keywords: Parkinson's Disease, Neurodegeneration, DTI-ALPS

Motivation: In the central nervous system, the dysfunction of " glymphatic system " potentially hinders α-synuclein clearance. Multiple system atrophy (MSA) as α-synucleinopathy diseases, the glymphatic system not been evaluated.

Goal(s): ALPS-index has been proposed as a new techology to evaluate the glymphatic system function.

Approach:

DTI-ALPS index to evaluate the glymphatic system function.
Structural MRI features of each subject were extract.
Group comparison, correlation analysis and granger causality test, mediation analysis were performed.

Results: MSA patients exhibited lower ALPS-index, and correlated with clinical symptoms and MSA-related neuropathological changes. The causality test indicated the ALPS-index changes may be the primary cause of the structural MRI changes.

Impact: Changes in glymphatic system status closely related to disease-related pathological in patients with multiple system atrophy.

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