Keywords: Aging, Aging
Motivation: Understanding age-associated changes in cerebral metabolism may provide mechanistic insights into the physiology of cognitive decline.
Goal(s): The goal of the study was to explore the effect of normal aging on neurometabolite levels in different brain regions using proton magnetic resonance spectroscopy (1H-MRS).
Approach: We performed 1H-MRS in brain regions associated with executive function, memory, and motor coordination in individuals without known disease recruited from the community and ranging from 19-57 years of age.
Results: We found a steady decline in markers of neuronal health and neurotransmission and an increase in markers of gliosis and/or neuroinflammation in the dorsolateral prefrontal cortex with age.
Impact: This study will inform future studies using 1H-MRS based normative brain metabolic data by mapping metabolic levels in healthy brain regions involved with executive function, memory, and motor coordination.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords