Abstract #4219

The exploration of establishing the IVIM-based Virtual Elastography conversion formula in Brain

Shuai Wang^1,2, Miaomiao Wang^1,2, Chenyue Liu^1,2, Kai Ai³, Congcong Liu^1,2, Xianjun Li^1,2, and Jian Yang^1,2

¹Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, ²Shaanxi Engineering Research Center of Computational Imaging and Medical Intelligence, Xi'an, China, ³Philips Healthcare, Xi'an, China

Synopsis

Keywords: White Matter, Elastography, IVIM,virtual-MRE,brain,Elastography

Motivation: The IVIM-based Virtual Elastography conversion formula based on liver data has been established and verified, but there are no studies using brain MRE data and IVIM data to explore the correlation between the two and establish the relevant conversion formula.

Goal(s): This study aims to validate the relationship between shear stiffness and sADC under different combinations of b-values and derive a conversion formula for vMRE in the brain.

Approach: IVIM and MRE data were collected and quantified in healthy adults.

Results: The correlation between sADC and shear stiffness has been confirmed, and the conversion formula of each brain region has been preliminarily established.

Impact: In this study, the feasibility of brain vMRE was verified for the first time based on brain MRE and IVIM data, and the conversion formulas of different brain regions were preliminatively established.

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