Abstract #4223

Gray matter loss and cognitive impairment in lung cancer is associated with blood-brain barrier permeability

dafu zhang¹, Huan Ma¹, wenwen cao², Zhiping Zhang¹, Jing Ai¹, Xiaoyong Zhang³, Yongzhou Xu⁴, and Zhenhui Li¹

¹Yunnan cancer hospital, Kunming, China, ²The second hospital of kunming medical university, kunming, China, ³Philips Healthcare, Chengdu, China, ⁴Philips Healthcare, Guangzhou, China

Synopsis

Keywords: Other Neurodegeneration, DSC & DCE Perfusion

Motivation: It is estimated that approximately 30% of cancer patients have detectable cognitive impairment before treatment. Despite these reports of cancer-related cognitive impairment, the mechanisms behind these phenomena remain unclear.

Goal(s): To investigate the relationship between blood-brain barrier (BBB) integrity, cerebral cortex volume, and cognitive dysfunction in untreated lung cancer (LC) patients with non-brain metastases.

Approach: 3D anatomical imaging and DCE-MRI imaging were performed. Cognitive function was assessed using Montreal Cognitive Assessment (MoCA).

Results: We observed an association between BBB leakiness and altered brain structure and cognitive function.

Impact: These findings also suggest that BBB damage may be one of the mechanisms contributing to cognitive impairment in lung cancer patients.

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