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Abstract #4224

Visualising and Segmenting the Thalamic Reticular Nucleus at 7T

Ross Gordon Marshall Shaw1, Penny Gowland1, Andrew Bagshaw2, and Richard Bowtell1
1Physics and Astronomy, SPMIC, University of Nottingham, Nottingham, United Kingdom, 2School of Psychology, University of Birmingham, Birmingham, United Kingdom

Synopsis

Keywords: White Matter, Microstructure, Thalamus, SWI

Motivation: The in-vivo study of the Thalamic Reticular Nucleus is of fundamental interest and relies on the development of a pipeline for visualising and segmenting the structure.

Goal(s): Presented is a a potential framework for inducing contrast at the TRN boundary that can guide future studies in creating functional maps of the TRN.

Approach: T1 weighted FLASH and susceptibility weighted imaging paradigms are explored in a number of participants and a novel segmentation approach is tested on these data sets.

Results: The TRN is visible to a variable degree in all participants and size stable masks of the structure are produced.

Impact: This work is a stepping stone in the creation of a robust framework for visualising and segmenting the Thalamic Reticular Nucleus. It can help guide future studies which seek to explore the TRN function in-vivo.

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