Abstract #4249

Improving EPI quality with GRAPPA in concurrent fMRI-fMRS at 7T

Shahrokh Abbasi-Rad^1,2,3, Robert Frost^1,2, Nutandev Bikkamane Jayadev⁴, Yulin Chang⁴, Ovidiu Andronesi^1,2, David Norris^3,5, Zoe Kourtzi⁶, Uzay Emir⁷, and André van der Kouwe^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany, ⁴Siemens Medical Solutions, Malvern, PA, United States, ⁵Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, ⁶University of Cambridge, Cambridge, United Kingdom, ⁷School of Health Sciences, Purdue University, West Lafayette, IN, United States

Synopsis

Keywords: Pulse Sequence Design, Brain

Motivation: To develop a sequence for high-quality concurrent measurement of BOLD signal changes (fMRI) and biochemicals metabolite concentrations (fMRS).

Goal(s): To implement parallel imaging with inline image reconstruction to improve fMRI image quality in concurrent fMRI-fMRS experiments at 7 T.

Approach: We modified an fMRS-fMRI sequence to start by acquiring reference lines for GRAPPA reconstruction. Then each TR consists of a semiLASER acquisition for single-voxel MRS, and a GRAPPA-accelerated 3D EPI acquisition.

Results: We obtained sufficient tSNR (30) map for the 3D EPI and a high SNR (59) and a narrow linewidth (9 Hz) for the spectrum.

Impact: The modified concurrent fMRI-fMRS pulse sequence enhances the fMRI component to enable whole-brain coverage, reduced distortion, and high spatial resolution, providing a powerful tool for neuroscientists to study the dynamics of neurochemicals simultaneous with the BOLD signal.

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