Keywords: Quantitative Imaging, Non-Proton, Data Analysis
Motivation: Sodium homeostasis is altered in abdominal pathologies such as cancer and cardiovascular disease, but established quantification techniques require an invasive biopsy.
Goal(s): Quantification of abdominal sodium content and T2* relaxation in abdominal organs and fluid-filled structures using 23Na-MRI.
Approach: Proton and sodium imaging of the abdomen was performed in 18 healthy volunteers using a 3D cones sequence and a sodium-tuned body coil on a clinical 3 T system.
Results: Mean total sodium concentration and long T2* relaxation times were measured in 8 organs and fluid-filled structures; results agreed with previously published work in human and animal models.
Impact: Quantitative 23Na-MRI measurements in healthy volunteers will serve as a baseline to evaluate pathological changes in hypertension and kidney tumour characterisation. This may assist in the assessment of treatment efficacy, thereby reducing the need for invasive biopsy techniques.
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