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Abstract #4286

Value of amide proton transfer (APT) and extracellular volume fraction (ECV) in differentiating P53- abnormal and wild-type endometrial cancer

Jun Li1, Shifeng Tian1, Hanyue Zhang1, Liangjie Lin2, Peng Sun2, Ailian Liu1, and Dandan Zheng3
1Department of Radiology, The First Affiliated Hospital, Dalian Medical University, Dalian, China, 2Philips (China) Investment Co., Ltd., Shanghai, China, 3Clinical & Technique Support, Philips Healthcare, Beijing, China

Synopsis

Keywords: Uterus, Cancer

Motivation: P53- abnormal and P53-wild-type endometrial cancer patients require distinct treatment owing to their unique pathological characteristics.

Goal(s): To investigate the diagnostic potential of APT and ECV measurements in distinguishing p53-abn from p53-wt in EC.

Approach: APT SI and T1 mapping-derived ECV values were compared between the two groups. Logistic regression was utilized to develop a predictive model that combines parameters, and receiver operating characteristic (ROC) analysis was conducted to assess diagnostic performance.

Results: APT and ECV can proficiently differentiate between p53-abn and p53-wt in endometrial cancer. Moreover, the discriminatory efficacy is enhanced significantly when both tests are employed concurrently.

Impact: P53- abnormal and P53-wild-type endometrial cancer patients require distinct treatment owing to their unique pathological characteristics. Precise and timely classification can precise endometrial cancer treatment, aiding in accurately classifying patients and devising personalized early treatment plans.

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Keywords

cancerendometrialtreatmentpatientsclinicalwildtypetumordiagnosticamidechinapreciseabnormalplansfractionemployedstatisticalclassifyingsignificance