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Abstract #4291

The Application of Time Dependent Diffusion Magnetic Resonance Imaging in Clinical Staging and Pathological Differentiation of Cervical Cancer

Junjun Li1, Kai Ai2, Yi Zhu3, Zhigang Wu4, Yi Xiao1, Yanhui Hao1, and Jianxin Guo1
1The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China, 2Philips Healthcare, Xi’an, China, 3Philips Healthcare, Beijing, China, 4Philips Healthcare, Shenzhen, China

Synopsis

Keywords: Uterus, Cancer, Cervical Cancer;Time-dependent diffusion magnetic resonance imaging

Motivation: Time-dependent diffusion magnetic resonance imaging (TDD-MRI) remains underexplored in the clinical staging and pathological differentiation of cervical cancer.

Goal(s): To investigate the application value of parameters derived from TDD-MRI (d, vin, Dex) in the clinical staging and pathological differentiation of cervical cancer.

Approach: We collected traditional DWI and TDD-MRI data from cervical cancer patients, comparing the respective parameters' efficacy in clinical staging and pathological differentiation.

Results: TDD-MRI outperformed ADC in staging cervical cancer, with combined parameters yielding an AUC of 0.90, sensitivity of 100%, and specificity of 70% for early-stage detection.

Impact: This study confirms the advantages of TDD-MRI parameters in the clinical staging of cervical cancer, especially for discerning early from advanced stages, offering greater accuracy than traditional DWI-ADC.

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