Abstract #4311

Pilot implementation of vendor-provided on-scanner gradient nonlinearity correction for breast tumor ADC measures in a prospective trial

Debosmita Biswas^1,2, Dariya Malyarenko³, Wesley Surento¹, Johannes Peeters⁴, Hye Shin Ahn^1,5, Dallas Turley⁶, Habib Rahbar¹, Wei Huang⁷, Thomas L Chenevert³, and Savannah C Partridge^1,2

¹Department of Radiology, University of Washington, Seattle, WA, United States, ²Department of Bioengineering, University of Washington, Seattle, WA, United States, ³Department of Radiology, University of Michigan, Ann Arbor, MI, United States, ⁴MR Clinical Science, Philips, Best, Netherlands, ⁵Department of Radiology, College of Medicine, Chung-Ang University Hospital, Seoul, Korea, Republic of, ⁶Philips Healthcare, Bothell, WA, United States, ⁷Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United States

Synopsis

Keywords: Breast, Gradients, Gradient Non linearity

Motivation: Improve accuracy of ADC measurement by correcting spatial nonuniformity of diffusion weighting caused by gradient nonlinearity (GNL) using novel vendor implemented on-scanner tools

Goal(s): Evaluate GNL correction of breast tumor ADC in a treatment response study

Approach: Implement on-scanner GNL correction, evaluate uncorrected and corrected tumor ADCs, evaluate GNL bias and ADC changes pre-treatment and post one cycle of neoadjuvant chemotherapy.

Results: Preliminary results from this study indicate adequate performance of the vendor implemented GNL correction of ADC in breast DWI assessment of response to neoadjuvant chemotherapy.

Impact: This pilot study demonstrates vendor-implemented GNL-correction (GNC) of spatially dependent b-value bias can dramatically simplify the process of obtaining more accurate ADC measures, which can improve robustness of ADC as a biomarker for treatment response.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.