Keywords: Urogenital, Bladder, Intravoxel Incoherent Motion, Amide Proton Transfer-Weighted Imaging, Bladder Cancer Grading
Motivation: Preoperative grading of bladder cancer (BC) impacts the choice of operative modality and prognosis of patients.
Goal(s): We aimed to perform an accurate and non-invasive preoperative grading method for BC by MRI sequences.
Approach: IVIM as well as APTw imaging were included in this study.
Results: The IVIM-related parameter (D, true-diffusion-coefficient) and APTw values were significantly different in low- and high-grade BC. Robust diagnostic efficacies were separately confirmed with high AUCs for IVIM and APTw in BC grading, and the diagnostic efficacy of the combined IVIM and APTw model was significantly higher compared to the individual parameters on their own.
Impact: Our findings suggest a complementary effect between the IVIM and APTw imaging parameters The combined model shows promise as a noninvasive biomarker for predicting BC histologic grading, aiding in the development of clinical therapeutic strategies, and assessing prognosis.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords