Abstract #4344

4D flow in Parkinson’s disease: cognitive decline corresponds with impaired circle of Willis haemodynamics

Ashley R Deane^1,2, Daniel J Mayall¹, Reza Shoorangiz^1,2,3, Alireza Sharifzadeh-Kermani⁴, Tim J Anderson^1,2,5, John C Dalrymple-Alford^1,2,6, Catherine A Morgan^7,8, and Tracy R Melzer^1,2,6

¹New Zealand Brain Research Institute, Christchurch, New Zealand, ²Department of Medicine, University of Otago, Christchurch, New Zealand, ³Department of Electrical and Computer Engineering, University of Canterbury, Christchurch, New Zealand, ⁴Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, ⁵Department of Neurology, Christchurch Hospital, Christchurch, New Zealand, ⁶School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand, ⁷School of Psychology and Centre for Brain Research, University of Auckland, Auckland, New Zealand, ⁸Centre for Advanced MRI, Auckland UniServices Limited, Auckland, New Zealand

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Motivation: The neurovascular changes associated with cognitive decline in Parkinson’s disease (PD) remain uncertain. Like Alzheimer’s disease, blood flow integrity may also play a significant role in maintaining cognitive function in PD.

Goal(s): To understand the relationship between cognitive impairment and circle of Willis anatomy and haemodynamics in PD.

Approach: 36 healthy controls and 81 individuals with PD completed 3T 4D flow MRI acquisition and an extensive neuropsychological battery.

Results: The PD group showed 10% lower total cerebral blood flow (ml/min) and 7% lower flow velocity (cm/min) which were associated with poorer cognition.

Impact: 4D flow MRI revealed hypoperfusion of the circle of Willis in Parkinson’s disease which corresponded with poorer cognition. These results support future targeting of vascular mechanisms to alleviate cognitive impairment in Parkinson’s disease.

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