Abstract #4345

Increase in Cerebral Oxygen Extraction Fraction in Early Parkinson’s Patients

Huseyin Enes Candan¹, Dongkyu Lee², Junghun Cho³, Hansol Lee⁴, and HyungJoon Cho²

¹Health Science and Technology, UNIST, Ulsan, Korea, Republic of, ²Department of Biomedical Engineering, UNIST, Ulsan, Korea, Republic of, ³Department of Biomedical Engineering, University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁴Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Motivation: Parkinson's disease is the fastest growing neurological disorder. However, comorbidities of the disease complicates its diagnosis and creates need for the discovery more biomarkers to help with diagnosis.

Goal(s): Our aim is to noninvasively measure the cerebral oxygen extraction fraction which is an important metric for cerebral oxygen metabolism and see if it can be utilized as a biomarker for early Parkinson's Disease.

Approach: MRI scans from early Parkinson's patients and healthy controls were obtained. Oxygen extraction fraction (OEF) maps for subjects were generated and two groups' oxygen metabolism was compared.

Results: An overall increase in cerebral OEF was observed for Parkinson's patients.

Impact: This study will potentially help with the diagnosis of early Parkinson's by providing another quantifiable biomarker. Additionally, difference in oxygen metabolism can help to understand Parkinson's disease better.

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